CUOME BIO LAB

CUOME Research Facility

High-efficiency strain, high-concentration probiotics, Extracellular vesicle-based research & development

Cultivation Laboratory

Designated Clean Bench for each strain

Culture System 3,000ML 2 Unit

Culture System 200ML 4 Unit  

100L Starter tank & Pass-box

Cell Counter, Electron Microscope

Microbial resource Bank

Reservoir of various microorganisms for multiple purposes: bio-agriculture, enhancing fishery and animal breeding environments, pharmaceutical raw materials, and Bacillus subtilis.

Development of highly active microbial strains through functional research.

Research on extracellular vesicles (exosome, EV)-based mass production technology and function.

생리 활성 연구실

Cell Culture

PCR

Real-time PCR

Western Blot, HPLC, Product development & QC

Cooperative Research Institute

Laboratory 1 Seoul Bio-hub

Study of Medicines obtained by culturing microorganisms.

Cell therapeutics study

Microbial functional studies

Laboratory 2 Challenge Center (Bio-process Engineering)

Microbial cultivation and production of microbe derived materials

Lactic acid bacteria (high concentration of heat treated probiotics, 5 trillion cells per 1g)

Food ingredients, health functional food raw materials, Active Pharmaceutical Ingredient, medical food

Endoplasmic reticulum derived from natural products and microorganisms

Aquatic/Veterinary Pharmaceutical Ingredient (scheduled to be used by subsidiary company Solfortu), Food, Cosmetic ingredients, Active Pharmaceutical Ingredient

Tasks performed by the research center

Screening & Utilization  of useful microorganism

Development of high efficiency strains and Functional Evaluation

Development of high-concentration pure probiotic cells and its culture mediumStudy of large-scale production of Extracellular vesicle(EV)

Natural and Microorganism derived Bio-agriculture, Marine/Veterinary Drugs and CRO

High concentration probiotics CUOME Q1 strain’s culture condition/ physiological activity study & product development.

Gene analysis of microbiome and study on relationship among immune cells

Study of Anti-cancer and Anti-inflammatory related immunomodulatory mechanism Based on Molecular immunology and development of Active Pharmaceutical Ingredients

Development of pathogens, antibiotics-resistant bacteria rapid detection kit and probiotics assay kit

Development of dermacosmetic ingredients, food & medicine for livestock & pets

Establishing standards and maintenance of strict quality control

Conducting national projects/industry-academia-government joint research

Research on the development of environmental microorganisms such as water quality improver

The world's highest concentration culture technology

Production of more than 8 Trillion Micrococcus per 1g/ 5 Trillion Bacillus per 1g

Lactobacillus plantarum(LPQ1), Lactobacillus lactis(LLQ1),Lactobacillus rhamnosus(LRQ1, LRM.Q3, LRVG.Q1, LRVG.Q2),Lactobacillus sakei Scalp Q2, Lacticaseibacillus rhamnosus Scalp Q5,Lactobacillus paracasei Q1, Lactobacillus salivarius(LSLQ1),Enterococcus faecalis(EFQ1), etc.

Cuomebio Microbial resource Bank

Operates various biological resource banks such as lactic acid bacteria, Bacillus subtilis, actinomycetes, and environmental improvement microorganisms

Core Technology

Microbial resource Bank

Reservoir of over 200 strains including lactic acid bacteria, Bacillus subtilis, industrial strains, and environmental strains

Selection of high-efficiency strains specialized for immunity

Retained Strains Q-Series LPQ1, LLQ1, LRVG.Q1, LR Scalp.Q5, EFQ1

Commercialized strain development process

Functional identification of two-way immunoactive strains

TIM & EV mass production technology

Target Ingredient Microbiome technology and EV mass production Technology

Safety & Stability

Bioprocess Engineering TechnologyCellular stability and stabilization technology

The world's highest concentration culture technology

Heat treatment technology that preserves immune modulating agents after cultivation

Microbial Resource Bank

CUOME BIO independently owns effective microorganism strains of unique activity through the company-affiliated microbial bank

Development process for commercialized strains

Exploration of source & Strain collection
Test for Immunoactivity
Selection of two-way immunoactive strain (capable to boost and suppress immune system)
Definition of strain function
Commercialization of high efficiency strains

LPQ1

 Lactobacillus plantarum Q1
LPQ1 : Probiotic strain with patented effects
Improvement of Mucosal Immunity
lgA (antibody for mucosal immunity) examined to increase by over 80% with a highly concentrated dose of LPQ1, tested on mice. Experimented to explore the amount of probiotic dosage that can beneficially alter the human  intestinal microbiome. (1Trillion cell count for adults)
# of application : 10-2022-0063685
Lactobacillus Plantarum Q1 Composition for improvement of mucosal immunity
Enhanced Production of Digestive Enzymes and Antimicrobial Effects
Produces digestive enzymes for enhanced digestion, and shows antimicrobial effects against Candida Albicans

Patent #  : 10-2310336
Lactobacillus Plantarum Q1 strain and its effect of producing digestive enzymes and antimicrobial actions
Effect against Hair Loss
Promotes growth of human dermal papilla cells to alleviate and prevent hair loss
Patent # : 10-2429565
Lactobacillus Plantarum Q1 composition for prevention and treatment of hair loss
Prevention of Muscular Damage
Helps to prevent muscular cell damage and recovery of muscular cells
Publicized Patent # : 10-2022-0081452
Lactobacillus Plantarum composition for prevention and treatment of muscular damage
Antibacterial and skin disease improvement effect on skin harmful bacteria
# of application :  10-2022-0152494
Composition containing Lactobacillus plantarum Q1 strain for antibacterial against skin harmful bacteria  and skin disease improvement

Other Experimental Data

Alleviation of Intestinal Inflammation
Highly concentrated dose of LPQ1 shown to be effective against irritable bowel syndrome and other intestinal inflammation symptoms (colitis), tested on mice. Higher effects were shown compared toPrednisolone (pharmaceutical) and Bacteroides thetaiotaomicron (intestinal beneficial bacteria treatment).

Skin elasticity enhancement effect

Confirmed the efficacy of LPQ1 pure bacteria to improve skin elasticity through inhibition of elastin synthesis and degradation

Immunomodulatory efficacy

It has been confirmed that the immune modulation ability is excellent as it has immune stimulant and inflammation suppression activities for major immune cells such as raw cells and dendritic cells.Cuome Bio's immune-related strain selection criteria screens immune-tolerant strains that can suppress inflammation, and finally selects strains with good dual immunity enhancing effect (two-way immunoactive strain).

Inhibition of Inflammation
Immunity Enhancement

Lipogenesis Inhibition and Fatty Liver Improvement Effect

By treating fat cells with LPQ1 heat-treated lactic acid bacteria, confirming the effect of suppressing adipogenesis and differentiation, confirming the mechanism of suppression of body fat increase and improvement of non-alcoholic fatty liver

LPQ1 Lipogenesis Inhibition Effects

LPQ1 무처리, 지방 비유도 케이스를 기준점으로 잡을 경우 위와 같이 그래프 보정 가능

LLQ1

 Lactococcus lactis Q1
락토코커스 락티스 Q1
Digestive enzyme production ability and antibacterial activity

LLQ1 high-concentration heat-treated lactic acid bacteria produce digestive enzymes to help digestion and absorption of food, and have antibacterial effect against Candida Albicans, which occurs frequently in immunocompromised patients.
Patent #  : 10-2310337
Lactococcus lactis Q1 strain having complex digestive enzyme production ability and antibacterial activity and uses thereof
Immune enhancement effect
The expression of immune cell surface factors and factors meaning immune enhancement such as cytokines are remarkably higherIt has been confirmed that the immune modulation ability is excellent as it has immunity enhancement and inflammation suppression activities for major immune cells such as raw cells and dendritic cells.
# of application10-2022-0019272((to be registered) : Immunity
Enhancement composition containing Lactococcus lactis Q1 strain

LRM.Q3

Lactobacillus rhamnosus M.Q3

Relieve Pulmonary Inflammation
LRM.Q3's EV(Extracellular Vesicle) was treated in mice, resulting in alleviating lung inflammation, which is confirmed as an excellent anti-inflammatory candidate that can reduce side effects and dependency on existing treatments (steroids, bronchodilators) that are avoided for long term treatment.
Promote muscle building & muscle loss prevention
When compared with various strains, it was confirmed that the LRM.Q3 strain has excellent ability to promote muscle cell differentiation.
C2C12-200μg/ml 1st Test Result

-

C2C12-200μg/ml 2nd Test Result

-

LRVG.Q1,Q2

Lactobacillus rhamnosus VG.Q1/Q2
락토바실러스 람노서스 VG.Q1/Q2
항균작용
대표적인 질 내 유해균에 대한 탁월한 항균력을 발휘함

99% 항균작용

스핀고모나스 파우치모빌리스
Sphingomonas paucimobilis

88% 항균작용

프로테우스 미라빌리스
Proteus mirabilis

70% 항균작용

크리세오 박테리움 글레움
Chryseobacterium gleum

28% 항균작용

가드넬라 바지날리스
Gardnerella vaginalis

LPC Q9

 Lactobacillus Paracasei Q9
락토바실러스 파라카세이 Q9
면역력 증가
대식세포의 포식 능력을 증강해 림프세포의 생식 능력과 혈청 lgG 수준 장점막의 기능 강화
미세먼지 과민반응 완화
대식 세포의 포식능력을 증강시켜 림프세포의 생식 능력과 혈청 lgG 수준 장점막의 기능 강화
음식물 알레르기 완화
L9에 의한 마우스 수지상세포 자극이 CD4+T 세포분화 유도, 알레르기 유도 마우스 비장세포에서 L9에 의한 Th1,Th2 밸런스 정상화
변비 치료
성인 40인 대상 임상 배변 원활, 대장균이 줄어들고 락토바실러스균과 비피더스균 증가
장건강 개선
배변횟수 증가 및 변 형태 개선하고 장내 유익균 증가, 유해균 수량 감소
결장염 완화
L9 섭취 시 DSS로 장염을 유발한 실험체의 장염이 개선됨

LPwg.q7

Lactobacillus plantarum Wild ginseng q7
락토바실러스 플란타럼 wild ginseng q7
항균 작용
독성이 강한 병원성 균주, 치주염 유발 균주, 위염 위암 유발 균주에 탁월한 항균 활성 작용
독성이 강한 병원성 균주

99.9% 항균작용

Staphylococcus aureus 
ATCC 6538
치주염 유발 균주

99.9% 항균작용

Porphyromonas gingivalis 
ATCC 33277
위염 및 위암 유발 균주

99.9% 항균작용

Helicobacter pylori
ATCC 700392

Major commercial strains

Bacterial Strains

Origins

Purpose of Use

Lactobacillus plantarum Q1

Kimchi

Health functional food, Cosmetics

Lactococcus lactis Q1

Kimchi

health functional food

Lactobacillus rhamnosus M.Q3 

Kimchi

Health functional food, Cosmetics

Lactobacillus rhamnosus VG.Q1

Vaginal cells

female vaginal health food

Lactobacillus rhamnosus VG.Q2

Vaginal cells

female vaginal health food

Lactobacillus sakei Scalp Q2

Scalp

Scalp health food, hair products

Lacticaseibacillus Scalp Q5

Scalp

Scalp health food, hair products

Lactobacillus plantarum wild ginseng Q7

Wild ginseng

food /health functional food

Lactobacillus paracasei Q9

Human

food /health functional food

Enterococcus faecalis Q1

Kimchi

Animal feed additives

Lactobacillus salivarius SW.Q1

Seaweeds

Marine organism immunity enhancerMarine water quality improver

Lactobacillus salivarius SW.Q2

Seaweeds

Marine organism immunity enhancerMarine water quality improver

Bacillus amyloliquefaciens Q2

Soil

Agricultural

Bacillus velezensis Q1

Soil

Agricultural

Bacillus subtilis Q1

Soil

Agricultural

Manufacturing Facilities

Cuome Bio's manufacturing facilities have been certified by a number of professional organizations.
We are equipped with Pilot's excellent facilities necessary for manufacturing and mass production.

Quality Certification

Hazard Analysis Critical Control Point (HACCP)
Good Manufacturing Practice
ISO 9001
Quality Management System
ISO 14001 Environmental Management System
Fermentor

30, 600, 800L Fermenter

Concentrator

UF, Vacuum, Continuous, Thin Film Concentrator

Dryer

Freeze, Spray, Vacuum Dryer

Fluid Bed Drying Granulator
Sterilizer

Continuous Sterilizer

Filter Press